|May 2012 · Vol. 24, No. 5
Try adding dexamethasone
to your clomiphene
Clomiphene-resistant women often ovulate, and then become pregnant, when treated with a combination of clomiphene and dexamethasone
Editor in Chief
CASE Infertility Dx: PCOS, anovulation
You have been treating a 33-year-old G0P0 woman who has polycystic ovary syndrome (PCOS) and anovulatory infertility with clomiphene citrate for three cycles, at escalating doses of 50 mg, 100 mg, and 150 mg daily. She has not ovulated, however, as determined by appropriately timed serum progesterone measurement.
What is your next step?