November 2008 · Vol. 20, No. 116 office tests to assess ovarian reserve, and what they tell you
Several tests of ovarian reserve are at your disposal. The help is welcome—but they’re not equally informative or reliable.
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Fast Track
Ovarian reserve is infiuenced by age, genetics, and environmental variables
Commonly cited criteria for normal ovarian reserve are:
An accurate antral follicle count requires an experienced sonographer and can be limited by fibroids or obesity
The age-related decline in AMH is gradual but measurable even in young women
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Samantha
F.
Butts,
MD, MSCEDr. Butts is Assistant Professor of Obstetrics and Gynecology, Division of Infertility and Reproductive Endocrinology, at University of Pennsylvania Medical School in Philadelphia. David
B.
Seifer,
MDDr. Seifer is Co-Director of Genesis Fertility and Reproductive Medicine at Maimonides Medical Center in Brooklyn, NY, and Professor of Obstetrics, Gynecology and Reproductive Sciences at Mount Sinai School of Medicine in New York City.
The University of Medicine and Dentistry of New Jersey (UMDNJ) owns a patent relating to the use of anti-Müllerian hormone/Müllerian inhibiting substance for predicting ovarian response in women with infertility. The patent is based in part on work that Dr. Seifer carried out while employed at UMDNJ. In accordance with UMDNJ policy, Dr. Seifer, a named inventor on this patent, assigned his interest in the invention to UMDNJ. UMDNJ has a licensing agreement with Diagnostic Systems Laboratory for the use of the claimed invention. Dr. Seifer receives a portion of the royalties, as determined by UMDNJ policy, that UMDNJ gains from this licensing agreement.
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